Ser92

Site Information
MDEtDAssAVkVKRA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 6855902

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 ) , western blotting ( 3 )
Disease tissue studied:	HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 ) , neuroblastoma ( 3 ) , melanoma skin cancer ( 4 )
Relevant cell line - cell type - tissue:	breast ( 2 ) , HeLa (cervical) ( 5 ) , SH-SY5Y (neural crest) ( 3 ) , WM239A (melanocyte) ( 4 )

Upstream Regulation
Putative in vivo kinases:	CK1D (human) ( 3 )
Kinases, in vitro:	CK1A (human) ( 7 )

References
1	Iguchi Y, et al. (2024) IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation. J Cell Biol 223 38197897 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Nonaka T, et al. (2016) Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43. J Biol Chem 291, 5473-83 26769969 Curated Info
4	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
5	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
6	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
7	Kametani F, et al. (2009) Identification of casein kinase-1 phosphorylation sites on TDP-43. Biochem Biophys Res Commun 382, 405-9 19285963 Curated Info