Thr140
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Home > Phosphorylation Site Page: > Thr140  -  AID (mouse)

Site Information
GVQIGIMtFKDYFYC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6835300

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 3 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
B lymphocyte-spleen ( 3 ) , HEK293T (epithelial) ( 2 ) , lymphocyte-blood ( 1 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 3 ) , PKCB (human) ( 3 ) , PKCH (human) ( 3 ) , PKCI (human) ( 3 )
Treatments:
anti-CD40 ( 3 ) , CpG ( 3 ) , IL-4 ( 3 ) , LPS ( 3 )

Downstream Regulation
Effects of modification on AID:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
DNA repair, inhibited ( 1 )
Induce interaction with:
RPA1 (mouse) ( 1 )

References 

1

Yamane A, et al. (2011) Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12, 62-9
21113164   Curated Info

2

Pavri R, et al. (2010) Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 143, 122-33
20887897   Curated Info

3

McBride KM, et al. (2008) Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205, 2585-94
18838546   Curated Info