Ser501
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Home > Phosphorylation Site Page: > Ser501  -  WASP (mouse)

Site Information
KRSRVIHssDEGEDQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449294

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 , 5 , 6 , 7 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
anthrax infection ( 5 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 )
Relevant cell line - cell type - tissue:
B lymphocyte ( 2 ) , blood ( 4 ) , liver ( 3 , 6 ) , RAW 267.4 (macrophage) ( 7 ) , spleen ( 5 , 6 )

Upstream Regulation
Treatments:
IFN-gamma ( 7 )

Downstream Regulation
Effects of modification on WASP:
activity, induced ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Liu C, et al. (2013) N-wasp is essential for the negative regulation of B cell receptor signaling. PLoS Biol 11, e1001704
24223520   Curated Info

3

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

4

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

5

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info