Ser483
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser483  -  WASP (human)

Site Information
KRSRAIHssDEGEDQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449294

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 5 ) , phospho-antibody ( 5 )
Disease tissue studied:
lymphoma ( 2 ) , Burkitt's lymphoma ( 2 )
Relevant cell line - cell type - tissue:
BAC1.2F5 (macrophage) ( 5 ) , BJAB (B lymphocyte) ( 2 ) , COS (fibroblast) ( 5 ) , Jurkat (T lymphocyte) ( 3 , 5 ) , platelet-blood ( 4 ) , Raji (B lymphocyte) ( 5 ) , Swiss 3T3 (fibroblast) ( 5 ) , U-937 (myeloid) ( 5 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 5 )
Kinases, in vitro:
CK2A1 (human) ( 5 )
Treatments:
DRB ( 5 ) , LY294002 ( 5 )

Downstream Regulation
Effects of modification on WASP:
molecular association, regulation ( 5 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 5 )
Induce interaction with:
ARPC3 (human) ( 5 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Rolland D, et al. (2014) Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas. Am J Pathol 184, 1331-42
24667141   Curated Info

3

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

4

Zahedi RP, et al. (2008) Phosphoproteome of resting human platelets. J Proteome Res 7, 526-34
18088087   Curated Info

5

Cory GO, Cramer R, Blanchoin L, Ridley AJ (2003) Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell 11, 1229-39
12769847   Curated Info