Tyr543
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Home > Phosphorylation Site Page: > Tyr543  -  SHP-1 (rat)

Site Information
SEyGNITyPPALRSA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449656

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on SHP-1:
molecular association, regulation ( 1 )
Induce interaction with:
PIK3R1 (rat) ( 1 )

References 

1

Yu Z, et al. (1998) SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 273, 3687-94
9452499   Curated Info