Ser704
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Home > Phosphorylation Site Page: > Ser704  -  FOXM1 (human)

Site Information
IDVPKPGsPEPQVSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449265

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 5 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 2 , 3 , 5 , 6 , 7 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
bone cancer ( 1 , 5 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 1 ) , COLO-829 (melanocyte) ( 1 ) , HeLa (cervical) ( 2 , 5 , 6 , 7 ) , Jurkat (T lymphocyte) ( 3 ) , U2OS (bone cell) ( 1 , 5 )

Upstream Regulation
Kinases, in vitro:
CDK4 (human) ( 5 ) , CDK6 (human) ( 5 )

Downstream Regulation
Effects of modification on FOXM1:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 5 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 5 )
Induce interaction with:
PIN1 (human) ( 1 )

References 

1

Kruiswijk F, et al. (2016) Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling. Oncogene 35, 2166-77
26279295   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Anders L, et al. (2011) A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 20, 620-34
22094256   Curated Info

6

Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8
19276368   Curated Info

7

Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5
15302935   Curated Info