Ser434
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Home > Phosphorylation Site Page: > Ser434  -  SREBP-1 (human)

Site Information
PPPsDAGsPFQSsPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6729302

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , HepG2 (hepatic) ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 1 )
Treatments:
DNA_binding ( 1 ) , insulin ( 1 ) , lithium ( 1 ) , peptide_antagonist ( 1 ) , SB415286 ( 1 ) , seliciclib ( 1 ) , siRNA ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on SREBP-1:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 1 )
Induce interaction with:
FBXW7 (human) ( 1 )

References 

1

Bengoechea-Alonso MT, Ericsson J (2009) A Phosphorylation Cascade Controls the Degradation of Active SREBP1. J Biol Chem 284, 5885-95
19126544   Curated Info

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