Thr497
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Home > Phosphorylation Site Page: > Thr497  -  PKCA (cow)

Site Information
MDGVttRtFCGTPDY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448598

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
Ca(2+) ( 2 ) , phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on PKCA:
enzymatic activity, induced ( 2 , 3 )

References 

1

Bornancin F, Parker PJ (1996) Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha. Curr Biol 6, 1114-23
8805373   Curated Info

2

Cazaubon S, Bornancin F, Parker PJ (1994) Threonine-497 is a critical site for permissive activation of protein kinase C alpha. Biochem J 301 ( Pt 2), 443-8
8042986   Curated Info

3

Cazaubon SM, Parker PJ (1993) Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. J Biol Chem 268, 17559-63
8349635   Curated Info