Ser657
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Home > Phosphorylation Site Page: > Ser657  -  PKCA (rat)

Site Information
QSDFEGFsYVNPQFV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448597

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 , 2 , 5 ) , hepatocyte ( 3 ) , vascular smooth muscle cell ('muscle, smooth') ( 4 )

Upstream Regulation
Putative in vivo kinases:
PKCA (rat) ( 3 )
Treatments:
diabetes ( 1 ) , electrical_stimulation ( 5 ) , GF109203X ( 4 ) , lysophosphatidylcholine ( 4 ) , okadaic_acid ( 5 ) , PAF ( 2 ) , PCA4248 ( 2 ) , phorbol_ester ( 3 ) , racepinefrine ( 3 )

Downstream Regulation
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Liao MH, et al. (2013) The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus. CNS Neurosci Ther 19, 329-36
23490331   Curated Info

2

Moriguchi S, Shioda N, Yamamoto Y, Fukunaga K (2010) Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. Neuroscience 166, 1158-66
20074623   Curated Info

3

Robles-Flores M, et al. (2008) Posttranslational modifications on protein kinase c isozymes. Effects of epinephrine and phorbol esters. Biochim Biophys Acta 1783, 695-712
18295358   Curated Info

4

Motley ED, et al. (2002) Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. Hypertension 39, 508-12
11882599   Curated Info

5

Thiels E, et al. (2000) Protein phosphatase-mediated regulation of protein kinase C during long-term depression in the adult hippocampus in vivo. J Neurosci 20, 7199-207
11007876   Curated Info