Ser325
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Home > Phosphorylation Site Page: > Ser325  -  FOXO1A (human)

Site Information
ssNAstIsGRLsPIM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449114

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 3 ) , 293 (epithelial) ( 2 , 3 ) , HeLa (cervical) ( 1 )

Upstream Regulation
Kinases, in vitro:
CK1A (human) ( 3 )
Treatments:
Akt-I-1 ( 1 ) , IGF-1 ( 3 ) , LY294002 ( 1 ) , wortmannin ( 3 )

Downstream Regulation
Effects of modification on FOXO1A:
intracellular localization ( 2 , 3 )

References 

1

Singh A, et al. (2010) Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell 21, 1140-52
20110348   Curated Info

2

Zhao X, et al. (2004) Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem J 378, 839-49
14664696   Curated Info

3

Rena G, et al. (2002) Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J 21, 2263-71
11980723   Curated Info

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