Ser9
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Site Information
SGRPRttsFAEsCKP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449111

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 7 , 9 , 52 , 86 ) , mass spectrometry ( 2 , 10 , 13 , 16 , 18 , 26 , 27 , 29 , 30 , 31 , 42 , 57 , 58 , 59 , 60 , 62 , 64 , 72 , 75 , 76 , 78 , 79 , 80 , 81 , 87 , 99 ) , microscopy-colocalization with upstream kinase ( 94 , 108 ) , mutation of modification site ( 7 , 52 , 53 , 88 , 129 , 130 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 9 , 12 , 14 , 23 , 25 , 28 , 33 , 35 , 36 , 40 , 41 , 43 , 44 , 47 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 63 , 65 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 77 , 82 , 83 , 84 , 85 , 86 , 89 , 90 , 91 , 94 , 96 , 97 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ) , western blotting ( 3 , 4 , 5 , 6 , 7 , 9 , 12 , 23 , 25 , 28 , 33 , 35 , 36 , 40 , 41 , 43 , 47 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 63 , 65 , 67 , 68 , 70 , 71 , 73 , 74 , 77 , 82 , 83 , 84 , 85 , 86 , 89 , 90 , 91 , 94 , 96 , 97 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 123 , 124 , 125 , 126 , 130 , 131 , 132 , 133 , 134 , 136 , 138 , 139 , 143 , 144 , 147 )
Disease tissue studied:
bipolar disprder ( 6 ) , colorectal cancer ( 55 ) , colorectal carcinoma ( 55 ) , liver cancer ( 89 ) , lung cancer ( 55 , 132 ) , mesothelioma ( 132 ) , non-small cell lung cancer ( 55 ) , lymphoma ( 118 ) , B cell lymphoma ( 118 ) , Burkitt's lymphoma ( 118 ) , neuroblastoma ( 4 , 36 , 71 , 119 ) , pancreatic cancer ( 23 , 44 , 55 ) , pancreatic carcinoma ( 55 ) , pancreatic islet cell cancer ( 23 ) , melanoma skin cancer ( 87 ) , diabetes mellitus ( 91 ) , type 2 diabetes ( 91 ) , Lafora disease ( 73 ) , schizophrenia ( 136 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 10 , 13 , 27 ) , 'brain, cerebral cortex' ( 69 , 114 , 124 , 135 , 136 ) , 'brain, hippocampus' ( 6 , 51 , 105 , 124 , 135 ) , 'brain, striatum' ( 9 , 124 , 135 , 137 ) , 'muscle, skeletal' ( 96 , 104 , 110 , 113 , 130 ) , 'muscle, skeletal' [RICTOR (mouse), homozygous knockout] ( 77 , 101 ) , 'neuron, cortical' ( 33 , 102 ) , 'neuron, cortical'-brain ( 83 , 121 , 141 ) , 'neuron, hippocampal' ( 33 ) , 'neuron, hippocampal'-brain ( 83 ) , 'neuron, striatal'-brain ( 122 ) , 'renal, podocyte' ( 54 ) , 'stem, embryonic' ( 96 , 130 ) , 'stem, induced pluripotent' ( 6 ) , 293 (epithelial) ( 65 , 90 , 118 , 146 ) , 293T (epithelial) ( 144 ) , 3T3 (fibroblast) ( 47 , 86 , 103 ) , 3T3 (fibroblast) [INSR (mouse), transfection] ( 86 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 129 , 132 , 142 , 143 , 146 ) , 3T3-L1 (fibroblast) ( 67 , 75 , 76 ) , A431 (epithelial) ( 55 ) , A549 (pulmonary) ( 55 ) , adipose tissue ( 96 , 110 ) , adipose tissue [RICTOR (mouse), homozygous knockout] ( 77 ) , artery-heart ( 140 ) , B lymphocyte ( 5 , 118 ) , BaF3 ('B lymphocyte, precursor') ( 86 ) , BaF3 ('B lymphocyte, precursor') [JAK3 (human), transfection] ( 2 ) , beta-pancreas ( 23 ) , BJAB (B lymphocyte) ( 118 ) , BMMC (mast) ( 147 ) , bone marrow ( 134 ) , brain ( 4 , 28 , 31 , 56 , 97 ) , brain [CDK5R1 (mouse)] ( 97 ) , brain [laforin (mouse), homozygous knockout] ( 73 ) , C2C12 (myoblast) ( 12 , 74 , 100 , 106 ) , CHO (fibroblast) [Tau iso8 (human)] ( 120 ) , colon ( 3 ) , COS (fibroblast) ( 25 , 73 , 86 , 129 ) , dendritic cell ( 103 ) , dendritic cell [MAPKAPK2 (mouse), homozygous knockout] ( 103 ) , dendritic cell [MSK1 (mouse), homozygous knockout] ( 103 ) , DLD1 (intestinal) ( 55 ) , E14tg2a ('stem, embryonic') ( 133 ) , embryo ( 31 ) , epithelial ( 63 , 94 ) , ESC ( 82 ) , fibroblast-lung ( 57 , 58 , 59 , 60 , 78 , 79 , 80 , 81 ) , GD25 (fibroblast) ( 139 ) , GL261 (glial) ( 70 ) , HCT15 (intestinal) ( 55 ) , heart ( 53 , 96 , 99 , 110 ) , HeLa (cervical) ( 55 ) , hepatocyte-liver ( 89 ) , hepatocyte-liver [TSC1 (mouse), homozygous knockout] ( 41 ) , HepG2 (hepatic) ( 89 ) , HL-1 (myocyte) ( 18 ) , HT-22 (neuron) ( 141 ) , HT-4 (neuron) ( 141 ) , keratinocyte ( 125 ) , keratinocyte-skin ( 123 ) , L cells (fibroblast) ( 109 ) , liver ( 7 , 26 , 30 , 31 , 62 , 68 , 72 , 96 , 110 , 126 , 127 , 130 ) , liver [leptin (mouse), homozygous knockout] ( 30 ) , liver [RICTOR (mouse), homozygous knockout] ( 77 ) , lymphocyte ( 136 ) , macrophage-bone marrow ( 138 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 29 ) , MCT cells (epithelial) ( 91 ) , MEF (fibroblast) ( 42 , 43 , 50 , 65 , 85 , 112 , 115 , 116 ) , MEF (fibroblast) [JNK1 (mouse), transfection] ( 90 ) , MEF (fibroblast) [Sin1 (mouse), homozygous knockout] ( 84 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 42 ) , MES (pulmonary) ( 132 ) , MIA PaCa-2 (pancreatic) ( 55 ) , MIN6 (pancreatic) ( 23 ) , mpkCCD (renal) ( 64 ) , muscle [laforin (mouse), homozygous knockout] ( 73 ) , myoblast ( 131 ) , myocyte-heart ( 88 , 107 ) , NCI-H1299 (pulmonary) ( 55 ) , Neuro-2a (neuron) ( 4 , 36 , 71 , 119 ) , neuron-'brain, cerebral cortex' ( 69 ) , neuron-'brain, hippocampus' ( 14 , 40 , 117 ) , neuron-'brain, hippocampus' [GSK3B (mouse)] ( 108 ) , neuron-dorsal root ganglia ( 25 , 35 ) , pancreatic ( 44 ) , parotid acinar-salivary gland ( 111 ) , parotid acinar-salivary gland [Akt1 (mouse)] ( 111 ) , PaTu (pancreatic) ( 55 ) , PEA-13 (fibroblast) ( 52 ) , prostate ( 94 ) , Raji (B lymphocyte) ( 118 ) , Rat1 (fibroblast) ( 146 ) , RAW 264.7 (macrophage) ( 16 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 87 ) , spleen ( 134 ) , SV40 ( 145 ) , Swiss 3T3 (fibroblast) ( 144 ) , U2OS (bone cell) [GR (human)] ( 129 ) , uterus ( 128 ) , WEHI-231 (B lymphocyte) ( 118 )

Upstream Regulation
Regulatory protein:
ACVR2B (mouse) ( 106 ) , Akt1 (human) ( 91 , 94 , 100 ) , Akt1 (mouse) ( 35 , 98 , 111 , 147 ) , Akt2 (mouse) ( 113 ) , APP (mouse) ( 119 ) , axin 1 (mouse) ( 40 ) , Bcr (mouse) ( 5 ) , BVR (mouse) ( 7 ) , CDC42 iso1 (mouse) ( 123 ) , CDK5 (mouse) ( 97 ) , CDK5R1 (mouse) ( 97 ) , CHIP (mouse) ( 98 ) , CRMP-2 (mouse) ( 35 ) , CTNNB1 (human) ( 90 ) , CTNNB1 (mouse) ( 90 ) , DISC1 (mouse) ( 83 ) , DNAPK (mouse) ( 92 ) , GSK3B (mouse) ( 89 , 138 ) , Huntingtin (mouse) ( 137 ) , ILK (mouse) ( 3 ) , ITGB1 (human) ( 139 ) , JNK1 (human) ( 90 ) , laforin (mouse) ( 73 ) , LIMS1 (mouse) ( 55 ) , LST8 (mouse) ( 112 ) , MEN1 (mouse) ( 23 ) , p70S6K (human) ( 91 ) , p70S6K (mouse) ( 115 ) , PDK1 (mouse) ( 96 ) , PHB (human) ( 74 ) , PPP2R5D (mouse) ( 56 ) , PTEN (mouse) ( 85 ) , RICTOR (human) ( 65 , 77 ) , RICTOR (mouse) ( 65 , 85 , 112 ) , RPS23 (mouse) ( 71 ) , SHP-2 (mouse) ( 142 ) , Sin1 (mouse) ( 116 ) , Tau (mouse) ( 14 ) , TSC1 (mouse) ( 41 , 115 ) , TSC2 (mouse) ( 115 )
Putative in vivo kinases:
Akt1 (mouse) ( 141 ) , Akt3 (human) ( 39 ) , KHS1 (human) ( 118 ) , PKACA (human) ( 146 ) , PKCA (human) ( 144 ) , PKCB (human) ( 144 ) , PKCH (human) ( 144 )
Kinases, in vitro:
p70S6K (human) ( 115 ) , p70S6K (mouse) ( 115 ) , PKACA (human) ( 146 )
Treatments:
4-HT ( 82 ) , A-443654 ( 86 ) , acadesine ( 89 , 102 ) , AG1478 ( 54 ) , Akt-I-1 ( 86 ) , Akt_activator_compound_11 ( 47 ) , Akt_inhibitor_VIII ( 86 ) , amino_acids ( 115 ) , antichymotrypsin ( 114 ) , BDNF ( 40 ) , BI-D1870 ( 103 ) , BIO ( 82 ) , bisindolylmaleimide ( 25 ) , blood pressure ( 88 ) , cAMP_analog ( 146 ) , canertinib ( 97 ) , CNQX ( 25 ) , cold_water_stress ( 105 ) , colforsin ( 146 ) , compound_C ( 89 ) , CP-681301 ( 97 ) , cpd22 ( 3 ) , culturing_of_cells ( 33 ) , cyclic_stretch ( 54 ) , deoxygenation ( 4 ) , DNP ( 147 ) , EGF ( 142 ) , estradiol ( 122 , 128 ) , ether ( 105 ) , fasting ( 68 , 89 ) , FGF1 ( 93 , 141 ) , fluoxetine ( 135 ) , food deprivation ( 105 ) , GF109203X ( 119 , 125 , 144 ) , ginkgolide K ( 4 ) , glucosamine ( 95 ) , glucose ( 91 ) , Go_6983 ( 123 ) , GSK-3_inhibitor_X ( 53 ) , H-89 ( 146 ) , H2O2 ( 54 ) , haloperidol ( 135 , 136 ) , high-fat diet ( 110 ) , idelalisib ( 5 ) , IgE ( 147 ) , IGF-1 ( 100 , 106 , 115 , 125 , 144 , 146 ) , IL-10 ( 134 ) , IL-22 ( 63 ) , IL-3 ( 86 ) , IL-6 ( 63 ) , inflammation ( 63 ) , insulin ( 12 , 13 , 27 , 37 , 61 , 67 , 74 , 77 , 86 , 91 , 96 , 101 , 102 , 104 , 110 , 112 , 116 , 140 , 143 , 144 , 145 ) , ionizing_radiation ( 129 ) , ischemia/reperfusion ( 4 ) , isoproterenol ( 53 , 146 ) , kainic_acid ( 25 ) , KU-0063794 ( 42 ) , L803-mts ( 126 ) , leptin ( 121 ) , LIF ( 82 , 133 ) , lithium ( 6 , 23 , 51 , 71 , 90 ) , LPA ( 144 , 146 ) , LPS ( 103 , 134 ) , LY294002 ( 12 , 13 , 37 , 82 , 86 , 91 , 102 , 128 , 133 , 141 , 144 , 146 ) , memantine ( 124 ) , MG132 ( 35 , 90 ) , MK-2206 ( 13 ) , MK-591 ( 28 ) , MPTP ( 122 ) , muscle contraction ( 113 ) , myostatin ( 106 ) , nerve_damage ( 35 ) , neurotrophin-3 ( 40 ) , Ni(2+) ( 50 ) , Nogo ( 36 ) , okadaic_acid ( 102 ) , PD98059 ( 12 , 70 , 141 ) , PDGF ( 67 , 115 , 144 ) , phorbol_ester ( 119 , 125 , 144 ) , physostigmine ( 124 ) , pilocarpine ( 69 , 124 ) , PKC-zeta_inhibitor ( 123 ) , pregnancy ( 107 ) , progesterone ( 128 ) , PUGNAc ( 143 ) , QLT0267 ( 109 ) , RAMH ( 9 ) , rapamycin ( 42 , 86 , 91 , 101 , 102 , 115 , 131 ) , refeeding ( 68 ) , Ro31-8220 ( 144 ) , SB216763 ( 121 ) , seliciclib ( 40 ) , serum ( 65 , 115 , 116 ) , serum_starvation ( 116 ) , siRNA ( 83 , 115 ) , SL0101 ( 103 ) , TDZD-8 ( 70 ) , tPA ( 52 ) , troglitazone ( 120 ) , U0126 ( 86 , 91 , 141 ) , UV ( 90 ) , Wnt3a ( 109 ) , wortmannin ( 40 , 106 , 115 , 123 , 128 , 144 , 146 )

Downstream Regulation
Effects of modification on GSK3B:
enzymatic activity, inhibited ( 52 , 56 , 88 , 128 , 129 , 130 , 137 , 141 , 146 ) , intracellular localization ( 69 ) , phosphorylation ( 130 )
Effects of modification on biological processes:
cell cycle regulation ( 5 ) , cell growth, altered ( 108 ) , cytoskeletal reorganization ( 88 , 108 ) , transcription, induced ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
type 2 diabetes ( 91 , 110 )

References 

1

Song Z, et al. (2018) PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo. Cell Mol Life Sci
30069702   Curated Info

2

Degryse S, et al. (2017) Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia
28852199   Curated Info

3

Ahmed AU, et al. (2017) Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis. J Immunol
28794235   Curated Info

4

Zhou X, et al. (2017) Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability. Oncotarget 8, 44682-44693
28591721   Curated Info

5

Varano G, et al. (2017) The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition. Nature 546, 302-306
28562582   Curated Info

6

Tobe BTD, et al. (2017) Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A 114, E4462-E4471
28500272   Curated Info

7

Hinds TD, et al. (2016) Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α. J Biol Chem 291, 25179-25191
27738106   Curated Info

8

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

9

Rapanelli M, et al. (2016) The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem 291, 21042-21052
27510032   Curated Info

10

Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36
27681418   Curated Info

11

Li K, et al. (2016) Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol 53, 391-401
25465240   Curated Info

12

Litwiniuk A, et al. (2016) FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells. PLoS One 11, e0146726
26785133   Curated Info

13

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

14

Vossel KA, et al. (2015) Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. J Cell Biol 209, 419-33
25963821   Curated Info

15

Song WJ, et al. (2015) Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). J Biol Chem 290, 2321-33
25477508   Curated Info

16

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

17

Sundaresan NR, et al. (2015) SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β. Mol Cell Biol 36, 678-92
26667039   Curated Info

18

Reinartz M, Raupach A, Kaisers W, Gödecke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. J Proteome Res 13, 4232-45
25162660   Curated Info

19

Riehle C, et al. (2014) Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol 34, 3450-60
25002528   Curated Info

20

Sarshad AA, et al. (2014) Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells. PLoS Genet 10, e1004390
24901984   Curated Info

21

Ryu J, et al. (2014) APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor. Cell Rep 7, 1227-38
24813896   Curated Info

22

Koraishy FM, et al. (2014) Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling. J Biol Chem 289, 14341-50
24692544   Curated Info

23

Desai SS, et al. (2014) GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation. J Biol Chem 289, 5386-98
24425879   Curated Info

24

Chen J, et al. (2014) ZiBuPiYin Recipe Protects db/db Mice from Diabetes-Associated Cognitive Decline through Improving Multiple Pathological Changes. PLoS One 9, e91680
24614172   Curated Info

25

Marques JM, et al. (2013) CRMP2 Tethers Kainate Receptor Activity to Cytoskeleton Dynamics during Neuronal Maturation. J Neurosci 33, 18298-310
24227739   Curated Info

26

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

27

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

28

Chu J, Lauretti E, Di Meco A, Praticò D (2013) FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo . Transl Psychiatry 3, e333
24301651   Curated Info

29

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

30

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

31

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

32

McAlpine CS, et al. (2012) Endoplasmic reticulum stress and glycogen synthase kinase-3β activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. Arterioscler Thromb Vasc Biol 32, 82-91
21998135   Curated Info

33

Diez H, Garrido JJ, Wandosell F (2012) Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons. PLoS One 7, e32715
22509246   Curated Info

34

Tang W, et al. (2011) A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell 21, 1038-50
22172670   Curated Info

35

Wakatsuki S, Saitoh F, Araki T (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol 13, 1415-23
22057101   Curated Info

36

Shen JY, et al. (2011) GSK-3β activation mediates Nogo-66-induced inhibition of neurite outgrowth in N2a cells. Neurosci Lett 505, 165-70
22019984   Curated Info

37

Case N, et al. (2011) Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem 286, 39450-6
21956113   Curated Info

38

Guo JP, Coppola D, Cheng JQ (2011) IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. J Biol Chem 286, 37389-98
21908616   Curated Info

39

O'Brien KA, Stojanovic-Terpo A, Hay N, Du X (2011) An important role for Akt3 in platelet activation and thrombosis. Blood 118, 4215-23
21821713   Curated Info

40

Fang WQ, et al. (2011) Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. J Neurosci 31, 13613-24
21940452   Curated Info

41

Yecies JL, et al. (2011) Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways. Cell Metab 14, 21-32
21723501   Curated Info

42

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

43

Xie X, et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A 108, 6474-9
21464307   Curated Info

44

Kennedy AL, et al. (2011) Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell 42, 36-49
21474066   Curated Info

45

Osawa Y, et al. (2011) Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J 25, 1133-44
21163859   Curated Info

46

Rodgers JT, Vogel RO, Puigserver P (2011) Clk2 and B56β Mediate Insulin-Regulated Assembly of the PP2A Phosphatase Holoenzyme Complex on Akt. Mol Cell 41, 471-9
21329884   Curated Info

47

Georgiades SN, et al. (2011) Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes. J Biol Inorg Chem 16, 195-208
20972690   Curated Info

48

Chen S, Wasserman DH, MacKintosh C, Sakamoto K (2011) Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab 13, 68-79
21195350   Curated Info

49

Chen CH, et al. (2011) ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3{beta}-Mediated Phosphorylation of Rictor. Sci Signal 4, ra10
21343617   Curated Info

50

Xu D, et al. (2010) Regulation of PTEN stability and activity by Plk3. J Biol Chem 285, 39935-42
20940307   Curated Info

51

Karyo R, et al. (2010) Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3. Mol Cell Neurosci 45, 449-55
20708687   Curated Info

52

Lin L, et al. (2010) tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway. Am J Pathol 177, 1687-96
20724593   Curated Info

53

Webb IG, et al. (2010) Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart. Cardiovasc Res 87, 494-503
20299330   Curated Info

54

Faour WH, Thibodeau JF, Kennedy CR (2010) Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes. Cell Signal 22, 1222-30
20362052   Curated Info

55

Eke I, et al. (2010) PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest 120, 2516-27
20530873   Curated Info

56

Kapfhamer D, et al. (2010) Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci 30, 8830-40
20592205   Curated Info

57

Guo A (2010) CST Curation Set: 9813; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

58

Guo A (2010) CST Curation Set: 9810; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

59

Guo A (2010) CST Curation Set: 9811; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

60

Guo A (2010) CST Curation Set: 9812; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

61

Kumar A, et al. (2010) Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 59, 1397-406
20332342   Curated Info

62

Possemato A (2010) CST Curation Set: 9729; Year: 2010; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

63

Nava P, et al. (2010) Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402
20303298   Curated Info

64

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

65

Treins C, et al. (2010) Rictor is a novel target of p70 S6 kinase-1. Oncogene 29, 1003-16
19935711   Curated Info

66

Saavedra A, et al. (2010) PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum. Cell Death Differ 17, 324-35
19745829   Curated Info

67

Ng Y, et al. (2010) Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane. J Biol Chem 285, 2245-57
19897488   Curated Info

68

Rodgers JT, Haas W, Gygi SP, Puigserver P (2010) Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab 11, 23-34
20074525   Curated Info

69

Perez-Costas E, et al. (2010) Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS One 5, e8911
20111716   Curated Info

70

Aguilar-Morante D, et al. (2010) Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8. PLoS One 5, e13879
21079728   Curated Info

71

Zhang YW, et al. (2009) A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron 64, 328-40
19914182   Curated Info

72

Guo A (2009) CST Curation Set: 7791; Year: 2009; Biosample/Treatment: tissue, liver(STK11)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

73

Puri R, Suzuki T, Yamakawa K, Ganesh S (2009) Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. J Biol Chem 284, 22657-63
19542233   Curated Info

74

Ande SR, Gu Y, Nyomba BL, Mishra S (2009) Insulin induced phosphorylation of prohibitin at tyrosine114 recruits Shp1. Biochim Biophys Acta 1793, 1372-8
19497338   Curated Info

75

Guo A (2009) CST Curation Set: 7450; Year: 2009; Biosample/Treatment: cell line, 3T3-L1/control; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

76

Guo A (2009) CST Curation Set: 7451; Year: 2009; Biosample/Treatment: cell line, 3T3-L1/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

77

Cybulski N, et al. (2009) mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A 106, 9902-7
19497867   Curated Info

78

Guo A (2009) CST Curation Set: 6843; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

79

Guo A (2009) CST Curation Set: 6840; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

80

Guo A (2009) CST Curation Set: 6839; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

81

Guo A (2009) CST Curation Set: 6842; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

82

Bechard M, Dalton S (2009) Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Mol Cell Biol 29, 2092-104
19223464   Curated Info

83

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

84

Feldman ME, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7, e38
19209957   Curated Info

85

Guertin DA, et al. (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15, 148-59
19185849   Curated Info

86

van Gorp AG, et al. (2009) AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B. Oncogene 28, 95-106
18836482   Curated Info

87

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

88

Matsuda T, et al. (2008) Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A 105, 20900-5
19106302   Curated Info

89

Horike N, et al. (2008) AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J Biol Chem 283, 33902-10
18801732   Curated Info

90

Hu D, et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29, 2317-24
18952597   Curated Info

91

Mariappan MM, et al. (2008) Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells. J Biol Chem 283, 30566-75
18701453   Curated Info

92

Surucu B, et al. (2008) In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis. J Biol Chem 283, 30025-33
18757368   Curated Info

93

Partovian C, et al. (2008) Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol Cell 32, 140-9
18851840   Curated Info

94

Majumder PK, et al. (2008) A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell 14, 146-55
18691549   Curated Info

95

Kang ES, et al. (2008) O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res 314, 2238-48
18570920   Curated Info

96

Bayascas JR, et al. (2008) Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol 28, 3258-72
18347057   Curated Info

97

Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32
18322105   Curated Info

98

Dickey CA, et al. (2008) Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A 105, 3622-7
18292230   Curated Info

99

Possemato A (2008) CST Curation Set: 3820; Year: 2008; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

100

Russell ST, Eley HL, Wyke SM, Tisdale MJ (2008) Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor. Biochem J 409, 751-9
17961125   Curated Info

101

Kumar A, et al. (2008) Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol 28, 61-70
17967879   Curated Info

102

Meske V, Albert F, Ohm TG (2008) Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau. J Biol Chem 283, 100-9
17971449   Curated Info

103

Zaru R, et al. (2007) The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol 8, 1227-35
17906627   Curated Info

104

Toole BJ, Cohen PT (2007) The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. Cell Signal 19, 1044-55
17257813   Curated Info

105

Ikeda Y, Ishiguro K, Fujita SC (2007) Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain. FEBS Lett 581, 891-7
17289030   Curated Info

106

Yang W, et al. (2007) Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1. J Biol Chem 282, 3799-808
17130121   Curated Info

107

Hilfiker-Kleiner D, et al. (2007) A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 128, 589-600
17289576   Curated Info

108

Kim WY, et al. (2006) Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron 52, 981-96
17178402   Curated Info

109

Oloumi A, Syam S, Dedhar S (2006) Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25, 7747-57
16799642   Curated Info

110

Nascimento EB, et al. (2006) Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 55, 3221-8
17130464   Curated Info

111

Limesand KH, Schwertfeger KL, Anderson SM (2006) MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol 26, 8840-56
16982679   Curated Info

112

Guertin DA, et al. (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11, 859-71
17141160   Curated Info

113

Sakamoto K, et al. (2006) Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle. Am J Physiol Endocrinol Metab 291, E1031-7
16803855   Curated Info

114

Padmanabhan J, Levy M, Dickson DW, Potter H (2006) Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain 129, 3020-34
16987932   Curated Info

115

Zhang HH, et al. (2006) S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell 24, 185-97
17052453   Curated Info

116

Jacinto E, et al. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125-37
16962653   Curated Info

117

Gärtner A, Huang X, Hall A (2006) Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation. J Cell Sci 119, 3927-34
16954147   Curated Info

118

Shi CS, et al. (2006) The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol 26, 6511-21
16914735   Curated Info

119

Wang ZF, et al. (2006) Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture. J Neurochem 98, 1167-75
16762022   Curated Info

120

d'Abramo C, Ricciarelli R, Pronzato MA, Davies P (2006) Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells. J Neurochem 98, 1068-77
16787414   Curated Info

121

Valerio A, et al. (2006) Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. J Biol Chem 281, 12950-8
16522636   Curated Info

122

D'Astous M, et al. (2006) Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Mol Pharmacol 69, 1492-8
16434614   Curated Info

123

Wu X, et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20, 571-85
16510873   Curated Info

124

De Sarno P, et al. (2006) In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors. Neurobiol Aging 27, 413-22
16464655   Curated Info

125

Li L, et al. (2006) Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J Biol Chem 281, 3237-43
16338928   Curated Info

126

Kaidanovich-Beilin O, Eldar-Finkelman H (2006) Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther 316, 17-24
16169938   Curated Info

127

Harada Y, et al. (2005) Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta. J Biol Chem 280, 31714-21
15980066   Curated Info

128

Chen B, et al. (2005) Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation. Mol Endocrinol 19, 1978-90
15845746   Curated Info

129

Kulikov R, Boehme KA, Blattner C (2005) Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Mol Cell Biol 25, 7170-80
16055726   Curated Info

130

McManus EJ, et al. (2005) Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J 24, 1571-83
15791206   Curated Info

131

Ohanna M, et al. (2005) Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 7, 286-94
15723049   Curated Info

132

Puc J, et al. (2005) Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell 7, 193-204
15710331   Curated Info

133

Paling NR, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-70
15328362   Curated Info

134

Bhattacharyya S, et al. (2004) Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood 104, 1100-9
15113757   Curated Info

135

Li X, et al. (2004) In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain. Neuropsychopharmacology 29, 1426-31
15039769   Curated Info

136

Emamian ES, et al. (2004) Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36, 131-7
14745448   Curated Info

137

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info

138

Troussard AA, et al. (2003) Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 278, 22374-8
12686550   Curated Info

139

Pankov R, et al. (2003) Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem 278, 18671-81
12637511   Curated Info

140

Brancaccio M, et al. (2003) Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 9, 68-75
12496958   Curated Info

141

Hashimoto M, et al. (2002) Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. J Biol Chem 277, 32985-91
12095987   Curated Info

142

Zhang SQ, et al. (2002) Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol 22, 4062-72
12024020   Curated Info

143

Vosseller K, Wells L, Lane MD, Hart GW (2002) Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 99, 5313-8
11959983   Curated Info

144

Fang X, et al. (2002) Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Mol Cell Biol 22, 2099-110
11884598   Curated Info

145

Nakae J, et al. (2001) Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt. Biochemistry 40, 11768-76
11570877   Curated Info

146

Fang X, et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A 97, 11960-5
11035810   Curated Info

147

Kitaura J, et al. (2000) Akt-dependent cytokine production in mast cells. J Exp Med 192, 729-40
10974038   Curated Info