Ser657
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Home > Phosphorylation Site Page: > Ser657  -  PKCA (cow)

Site Information
QSDFEGFsYVNPQFV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448597

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
phorbol_ester ( 3 )

Downstream Regulation
Effects of modification on PKCA:
activity, induced ( 2 ) , enzymatic activity, induced ( 3 ) , phosphorylation ( 1 ) , protein conformation ( 2 ) , protein stabilization ( 1 , 2 , 3 )

References 

1

Gysin S, Imber R (1997) Phorbol-ester-activated protein kinase C-alpha lacking phosphorylation at Ser657 is down-regulated by a mechanism involving dephosphorylation. Eur J Biochem 249, 156-60
9363767   Curated Info

2

Bornancin F, Parker PJ (1997) Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. J Biol Chem 272, 3544-9
9013603   Curated Info

3

Gysin S, Imber R (1996) Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane. Eur J Biochem 240, 747-50
8856079   Curated Info