Ser889
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Home > Phosphorylation Site Page: > Ser889  -  NMDAR1 (rat)

Site Information
AITSTLAssFKRRRs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449107

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 1 , 2 , 4 ) , phosphoamino acid analysis ( 4 ) , phosphopeptide mapping ( 4 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 4 ) , 293 (epithelial) ( 1 , 2 , 4 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 3 )

Downstream Regulation
Effects of modification on NMDAR1:
molecular association, regulation ( 3 )
Inhibit interaction with:
Calmodulin (rat) ( 3 )

References 

1

Xu M, Smothers CT, Woodward JJ (2011) Effects of ethanol on phosphorylation site mutants of recombinant N-methyl-D-aspartate receptors. Alcohol 45, 373-80
21163614   Curated Info

2

Jackson MF, et al. (2006) Protein kinase C enhances glycine-insensitive desensitization of NMDA receptors independently of previously identified protein kinase C sites. J Neurochem 96, 1509-18
16417568   Curated Info

3

Hisatsune C, et al. (1997) Phosphorylation-dependent regulation of N-methyl-D-aspartate receptors by calmodulin. J Biol Chem 272, 20805-10
9252405   Curated Info

4

Tingley WG, Roche KW, Thompson AK, Huganir RL (1993) Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain. Nature 364, 70-3
8316301   Curated Info

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