Ser329
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Home > Phosphorylation Site Page: > Ser329  -  MC4R (human)

Site Information
LGGLCDLssRY____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449102

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , Neuro-2a (neuron) ( 1 )

Upstream Regulation
Putative in vivo kinases:
GRK2 (cow) ( 2 )
Treatments:
MSH ( 2 )

Downstream Regulation
Effects of modification on MC4R:
activity, inhibited ( 1 ) , intracellular localization ( 1 ) , receptor internalization, altered ( 2 ) , receptor recycling, inhibited ( 1 )

References 

1

McDaniel FK, et al. (2012) Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH). J Biol Chem 287, 21873-90
22544740   Curated Info

2

Shinyama H, Masuzaki H, Fang H, Flier JS (2003) Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology 144, 1301-14
12639913   Curated Info

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