Ser118
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Home > Phosphorylation Site Page: > Ser118  -  PDE4B (mouse)

Site Information
GHSQRREsFLYRSDs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449097

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 5 , 6 , 7 , 8 , 9 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
melanoma skin cancer ( 9 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 2 ) , 'fat, brown' ( 7 ) , brain ( 6 , 7 ) , heart ( 5 , 7 ) , hepatocyte ( 1 ) , kidney ( 7 ) , liver ( 7 ) , mpkCCD (renal) ( 8 ) , pancreas ( 7 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 9 ) , spleen ( 7 )

Upstream Regulation
Regulatory protein:
CDK5 (mouse) ( 2 )
Kinases, in vitro:
AMPKA1 (human) ( 1 ) , PKACA (human) ( 1 )

Downstream Regulation
Effects of modification on PDE4B:
enzymatic activity, induced ( 2 )

References 

1

Johanns M, et al. (2016) AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nat Commun 7, 10856
26952277   Curated Info

2

Plattner F, et al. (2015) The role of ventral striatal cAMP signaling in stress-induced behaviors. Nat Neurosci 18, 1094-100
26192746   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

6

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

7

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

8

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

9

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info