Ser707
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Home > Phosphorylation Site Page: > Ser707  -  Tau (rat)

Site Information
GAEIVyKsPVVsGDt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449081

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 29 ) , immunoassay ( 1 , 4 ) , immunoprecipitation ( 16 ) , mass spectrometry ( 9 , 10 , 13 , 19 ) , mutation of modification site ( 20 ) , peptide sequencing ( 29 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 7 , 8 , 11 , 12 , 14 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 ) , phosphoamino acid analysis ( 29 ) , western blotting ( 1 , 2 , 3 , 4 , 7 , 8 , 11 , 12 , 14 , 15 , 16 , 17 , 18 , 20 , 21 , 26 , 27 )
Disease tissue studied:
Alzheimer's disease ( 14 , 23 ) , adrenal cancer ( 12 , 18 ) , pheochromocytoma ( 12 , 18 ) , neuroblastoma ( 1 , 7 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 10 ) , 'brain, cerebellum' ( 10 ) , 'brain, cerebral cortex' ( 10 , 17 ) , 'brain, hippocampus' ( 7 , 8 , 11 , 12 , 16 , 17 , 26 ) , 'neuron, cerebellar granule'-brain ( 23 ) , 'neuron, cortical' ( 21 ) , 'neuron, cortical' [APP (human)] ( 20 ) , 'neuron, cortical'-brain ( 1 ) , 'neuron, hippocampal'-brain ( 4 ) , adipose tissue ( 10 ) , brain ( 14 , 15 , 17 , 18 , 19 , 27 , 28 , 29 ) , heart ( 10 ) , intestine ( 10 ) , kidney ( 10 ) , liver ( 10 , 13 ) , lung ( 10 ) , muscle ( 10 ) , Neuro-2a (neuron) ( 7 ) , neuron-'brain, hippocampus' ( 3 ) , pancreas ( 10 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 9 ) , PC-12 (chromaffin) ( 9 , 12 , 18 ) , SH-SY5Y (neural crest) ( 1 ) , stomach ( 10 ) , testis ( 10 ) , thymus ( 10 )

Upstream Regulation
Regulatory protein:
APP (rat) ( 3 ) , HUNIN (human) ( 3 ) , PPP2CA (rat) ( 7 )
Putative upstream phosphatases:
PPP2CA (rat) ( 16 )
Treatments:
AG1024 ( 7 ) , AG1478 ( 7 ) , anoxia ( 23 ) , beta-amyloid_42 ( 2 ) , calyculin_A ( 11 ) , Cdk2/5_inhibitor ( 27 ) , ciclosporin ( 20 ) , colforsin ( 27 ) , depolarization ( 20 ) , development ( 17 ) , DON ( 15 ) , fasting ( 15 ) , folic acid ( 16 ) , H-CHO ( 22 ) , H2O2 ( 21 ) , homocysteine ( 8 , 16 ) , hypothermia prone ( 1 ) , hypoxia ( 4 ) , isoproterenol ( 26 ) , lithium ( 27 ) , low_glucose ( 23 ) , melatonin ( 11 , 26 ) , okadaic_acid ( 14 , 15 , 28 ) , PD98059 ( 27 ) , PDGF ( 9 ) , PP2 ( 7 ) , PUGNAc ( 28 ) , Rp-cAMPS ( 27 ) , SB203580 ( 27 ) , SB415286 ( 20 ) , thiamet-G ( 18 ) , tungstate ( 22 ) , vitamin_B12 ( 16 ) , Zn(2+) ( 7 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 26 )

References 

1

Pražienková V, et al. (2019) Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons. J Alzheimers Dis
30689580   Curated Info

2

Oliveira JM, et al. (2015) Amyloid-β Modulates Both AβPP and Tau Phosphorylation. J Alzheimers Dis 45, 495-507
25589714   Curated Info

3

Chai GS, et al. (2014) Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull 30, 923-35
25391447   Curated Info

4

Zhang CE, et al. (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14, 107-16
24993525   Curated Info

5

Liu X, et al. (2014) Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis 40, 419-27
24448782   Curated Info

6

Nie J, Duan L, Yan Z, Niu Q (2013) Tau hyperphosphorylation is associated with spatial learning and memory after exposure to benzo[a]pyrene in SD rats. Neurotox Res 24, 461-71
23508864   Curated Info

7

Xiong Y, et al. (2013) Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34, 745-56
22892311   Curated Info

8

Chai GS, et al. (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124, 388-96
23157378   Curated Info

9

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30
22027198   Curated Info

10

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

11

Yang X, et al. (2011) Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol 25, 1118-25
20542922   Curated Info

12

Lu Y, et al. (2011) Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. J Biol Chem 286, 20569-81
21489990   Curated Info

13

Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781   Curated Info

14

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

15

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

16

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

17

Inukai Y, et al. (2008) Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett 582, 2899-904
18656473   Curated Info

18

Yuzwa SA, et al. (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4, 483-90
18587388   Curated Info

19

Guo A (2007) CST Curation Set: 2239; Year: 2007; Biosample/Treatment: tissue, brain/ischemia 20'; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

20

Pierrot N, et al. (2006) Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. J Biol Chem 281, 39907-14
17085446   Curated Info

21

Galas MC, et al. (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281, 19296-304
16675464   Curated Info

22

Gómez-Ramos A, et al. (2006) Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J Neurosci Res 83, 264-73
16397900   Curated Info

23

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

24

Yamamoto H, et al. (2005) Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain. J Neurochem 94, 1438-47
16000144   Curated Info

25

Li YK, et al. (2005) [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons.] Sheng Li Xue Bao 57, 154-60
15830099   Curated Info

26

Wang XC, et al. (2005) Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng Li Xue Bao 57, 7-12
15719129   Curated Info

27

Liu SJ, et al. (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279, 50078-88
15375165   Curated Info

28

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info

29

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info