Ser733
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Home > Phosphorylation Site Page: > Ser733  -  Tau (rat)

Site Information
GSIDMVDsPQLATLA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449083

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 ) , western blotting ( 2 , 3 , 4 )
Disease tissue studied:
Alzheimer's disease ( 2 , 5 ) , adrenal cancer ( 4 ) , pheochromocytoma ( 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 1 ) , 'neuron, cerebellar granule'-brain ( 5 ) , adipose tissue ( 1 ) , brain ( 2 , 3 , 4 , 6 ) , heart ( 1 ) , intestine ( 1 ) , kidney ( 1 ) , lung ( 1 ) , muscle ( 1 ) , pancreas ( 1 ) , PC-12 (chromaffin) ( 4 ) , stomach ( 1 )

Upstream Regulation
Treatments:
anoxia ( 5 ) , okadaic_acid ( 2 , 3 , 6 ) , PUGNAc ( 6 ) , thiamet-G ( 4 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

3

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

4

Yuzwa SA, et al. (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4, 483-90
18587388   Curated Info

5

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

6

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info