Ser715
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Home > Phosphorylation Site Page: > Ser715  -  Tau (rat)

Site Information
PVVsGDtsPRHLSNV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449082

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 23 ) , immunoassay ( 1 ) , immunoprecipitation ( 12 ) , mass spectrometry ( 5 , 6 , 8 , 11 , 15 ) , mutation of modification site ( 16 ) , peptide sequencing ( 23 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 7 , 9 , 10 , 12 , 13 , 14 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ) , phosphoamino acid analysis ( 23 ) , western blotting ( 1 , 2 , 3 , 4 , 7 , 9 , 10 , 12 , 13 , 14 , 16 , 17 , 20 , 21 )
Disease tissue studied:
Alzheimer's disease ( 9 , 19 ) , adrenal cancer ( 7 , 13 , 14 ) , pheochromocytoma ( 7 , 13 , 14 ) , neuroblastoma ( 1 , 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 6 ) , 'brain, cerebellum' ( 6 ) , 'brain, cerebral cortex' ( 6 ) , 'brain, forebrain' ( 11 ) , 'brain, hippocampus' ( 4 , 7 , 12 , 20 ) , 'neuron, cerebellar granule'-brain ( 19 ) , 'neuron, cortical' ( 17 ) , 'neuron, cortical' [APP (human)] ( 16 ) , 'neuron, cortical'-brain ( 1 ) , 'neuron, hippocampal'-brain ( 3 ) , adipose tissue ( 6 ) , brain ( 9 , 10 , 13 , 15 , 21 , 22 , 23 ) , heart ( 6 ) , intestine ( 6 ) , kidney ( 6 ) , liver ( 6 , 8 ) , lung ( 6 ) , muscle ( 6 ) , Neuro-2a (neuron) ( 4 ) , neuron-'brain, hippocampus' ( 2 ) , pancreas ( 6 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 5 ) , PC-12 (chromaffin) ( 5 , 7 , 13 , 14 ) , SH-SY5Y (neural crest) ( 1 ) , stomach ( 6 ) , testis ( 6 ) , thymus ( 6 )

Upstream Regulation
Regulatory protein:
APP (rat) ( 2 ) , HUNIN (human) ( 2 ) , PPP2CA (rat) ( 4 , 14 )
Putative upstream phosphatases:
PPP2CA (rat) ( 12 )
Treatments:
AG1024 ( 4 ) , AG1478 ( 4 ) , anoxia ( 19 ) , Cdk2/5_inhibitor ( 21 ) , ciclosporin ( 16 ) , colforsin ( 21 ) , depolarization ( 16 ) , DON ( 10 ) , fasting ( 10 ) , folic acid ( 12 ) , H-CHO ( 18 ) , H2O2 ( 17 ) , homocysteine ( 12 ) , hypothermia ( 1 ) , hypoxia ( 3 ) , isoproterenol ( 20 ) , lithium ( 21 ) , low_glucose ( 19 ) , melatonin ( 20 ) , okadaic_acid ( 9 , 10 , 22 ) , palm 11 -PrRP3 ( 1 ) , PD98059 ( 21 ) , PP2 ( 4 ) , PUGNAc ( 22 ) , Rp-cAMPS ( 21 ) , SB203580 ( 21 ) , SB415286 ( 16 ) , thiamet-G ( 13 ) , tungstate ( 18 ) , vitamin_B12 ( 12 ) , Zn(2+) ( 4 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 14 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 20 )

References 

1

Pražienková V, et al. (2019) Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons. J Alzheimers Dis
30689580   Curated Info

2

Chai GS, et al. (2014) Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull 30, 923-35
25391447   Curated Info

3

Zhang CE, et al. (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14, 107-16
24993525   Curated Info

4

Xiong Y, et al. (2013) Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34, 745-56
22892311   Curated Info

5

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30
22027198   Curated Info

6

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

7

Lu Y, et al. (2011) Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. J Biol Chem 286, 20569-81
21489990   Curated Info

8

Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781   Curated Info

9

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

10

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

11

Edbauer D, et al. (2009) Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8, 681-95
19054758   Curated Info

12

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

13

Yuzwa SA, et al. (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4, 483-90
18587388   Curated Info

14

Chen S, Li B, Grundke-Iqbal I, Iqbal K (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 283, 10513-21
18245083   Curated Info

15

Guo A (2007) CST Curation Set: 2239; Year: 2007; Biosample/Treatment: tissue, brain/ischemia 20'; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

16

Pierrot N, et al. (2006) Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. J Biol Chem 281, 39907-14
17085446   Curated Info

17

Galas MC, et al. (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281, 19296-304
16675464   Curated Info

18

Gómez-Ramos A, et al. (2006) Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J Neurosci Res 83, 264-73
16397900   Curated Info

19

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

20

Wang XC, et al. (2005) Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng Li Xue Bao 57, 7-12
15719129   Curated Info

21

Liu SJ, et al. (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279, 50078-88
15375165   Curated Info

22

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info

23

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info