Ser573
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Home > Phosphorylation Site Page: > Ser573  -  Tau (rat)

Site Information
NVRSKIGsTENLKHQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447930

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 14 ) , mass spectrometry ( 1 , 8 ) , mutation of modification site ( 1 , 17 ) , phospho-antibody ( 1 , 3 , 4 , 5 , 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ) , western blotting ( 1 , 2 , 3 , 5 , 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 )
Disease tissue studied:
Alzheimer's disease ( 12 , 19 ) , adrenal cancer ( 11 , 15 , 16 , 17 ) , pheochromocytoma ( 11 , 15 , 16 , 17 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 4 ) , 'brain, hippocampus' ( 7 , 10 , 11 , 14 ) , 'neuron, cerebellar granule'-brain ( 19 ) , 'neuron, hippocampal'-brain ( 2 , 18 ) , 293 (epithelial) ( 17 ) , brain ( 12 , 13 , 15 , 20 ) , E.coli (bacterial) ( 1 ) , heart ( 8 ) , kidney ( 8 ) , neuron-'brain, hippocampus' ( 5 , 17 ) , PC-12 (chromaffin) ( 11 , 15 , 16 , 17 )

Upstream Regulation
Regulatory protein:
APP (rat) ( 5 ) , HUNIN (human) ( 5 ) , PKCI (rat) ( 17 ) , PPP2CA (rat) ( 4 , 16 )
Putative in vivo kinases:
MARK1 (rat) ( 18 ) , MARK2 (rat) ( 17 )
Kinases, in vitro:
BRSK1 iso2 (human) ( 9 )
Putative upstream phosphatases:
PPP2CA (rat) ( 14 )
Treatments:
anoxia ( 19 ) , calyculin_A ( 10 ) , DON ( 13 ) , electrical_stimulation ( 18 ) , folic acid ( 14 ) , homocysteine ( 7 , 14 ) , hypoxia ( 6 ) , melatonin ( 10 ) , memantine ( 4 ) , okadaic_acid ( 12 , 13 , 20 ) , PUGNAc ( 20 ) , thiamet-G ( 15 ) , vitamin_B12 ( 14 )

Downstream Regulation
Effects of modification on Tau:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 16 )

References 

1

Despres C, et al. (2017) Identification of the Tau phosphorylation pattern that drives its aggregation. Proc Natl Acad Sci U S A 114, 9080-9085
28784767   Curated Info

2

Deng SS, et al. (2015) Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409. J Biol Chem 290, 3149-60
25512381   Curated Info

3

Oliveira JM, et al. (2015) Amyloid-β Modulates Both AβPP and Tau Phosphorylation. J Alzheimers Dis 45, 495-507
25589714   Curated Info

4

Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K (2015) Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment. PLoS One 10, e0145441
26697860   Curated Info

5

Chai GS, et al. (2014) Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull 30, 923-35
25391447   Curated Info

6

Zhang CE, et al. (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14, 107-16
24993525   Curated Info

7

Chai GS, et al. (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124, 388-96
23157378   Curated Info

8

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

9

Rodríguez-Asiain A, et al. (2011) Brain Specific Kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment. Biochim Biophys Acta 1811, 1124-35
22020259   Curated Info

10

Yang X, et al. (2011) Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol 25, 1118-25
20542922   Curated Info

11

Lu Y, et al. (2011) Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. J Biol Chem 286, 20569-81
21489990   Curated Info

12

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

13

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

14

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

15

Yuzwa SA, et al. (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4, 483-90
18587388   Curated Info

16

Chen S, Li B, Grundke-Iqbal I, Iqbal K (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 283, 10513-21
18245083   Curated Info

17

Chen YM, et al. (2006) Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci U S A 103, 8534-9
16717194   Curated Info

18

Jeon S, Kim YS, Park J, Bae CD (2005) Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus. J Neurochem 95, 1608-18
16238695   Curated Info

19

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

20

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info