Ser546
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Home > Phosphorylation Site Page: > Ser546  -  Tau (rat)

Site Information
VVRtPPKsPSASKsR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449080

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 5 ) , mass spectrometry ( 2 , 3 ) , peptide sequencing ( 5 ) , phospho-antibody ( 1 , 4 ) , phosphoamino acid analysis ( 5 ) , western blotting ( 4 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 1 , 2 ) , 'brain, forebrain' ( 3 ) , adipose tissue ( 2 ) , brain ( 5 ) , heart ( 2 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 ) , lung ( 2 ) , muscle ( 2 ) , PC-12 (chromaffin) ( 4 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Regulatory protein:
PPP2CA (rat) ( 1 , 4 )
Treatments:
memantine ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 4 )

References 

1

Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K (2015) Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment. PLoS One 10, e0145441
26697860   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Edbauer D, et al. (2009) Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8, 681-95
19054758   Curated Info

4

Chen S, Li B, Grundke-Iqbal I, Iqbal K (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 283, 10513-21
18245083   Curated Info

5

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info