Thr542
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Home > Phosphorylation Site Page: > Thr542  -  Tau (rat)

Site Information
KKVAVVRtPPKsPSA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449079

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 14 ) , immunoprecipitation ( 7 ) , mass spectrometry ( 5 , 6 ) , peptide sequencing ( 14 ) , phospho-antibody ( 1 , 2 , 4 , 7 , 8 , 9 , 10 , 11 , 12 ) , phosphoamino acid analysis ( 14 ) , western blotting ( 1 , 4 , 7 , 8 , 9 , 10 )
Disease tissue studied:
Alzheimer's disease ( 12 ) , adrenal cancer ( 8 , 9 ) , pheochromocytoma ( 8 , 9 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 5 ) , 'brain, cerebellum' ( 5 ) , 'brain, cerebral cortex' ( 2 , 5 ) , 'brain, forebrain' ( 6 ) , 'brain, hippocampus' ( 1 , 4 , 7 ) , 'neuron, cerebellar granule'-brain ( 12 ) , 'neuron, cortical' ( 10 ) , adipose tissue ( 5 ) , brain ( 8 , 14 ) , heart ( 5 ) , intestine ( 5 ) , kidney ( 5 ) , liver ( 5 ) , lung ( 5 ) , muscle ( 5 ) , PC-12 (chromaffin) ( 8 , 9 ) , spinal cord ( 1 ) , testis ( 5 ) , thymus ( 5 )

Upstream Regulation
Regulatory protein:
PPP2CA (rat) ( 2 , 9 )
Putative upstream phosphatases:
PPP2CA (rat) ( 7 )
Treatments:
anoxia ( 12 ) , folic acid ( 7 ) , H-CHO ( 11 ) , H2O2 ( 10 ) , heat_shock ( 10 ) , homocysteine ( 4 , 7 ) , juglone ( 10 ) , memantine ( 2 ) , thiamet-G ( 8 ) , tungstate ( 11 ) , vitamin_B12 ( 7 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 9 )

References 

1

Moszczynski AJ, et al. (2018) Pathologic Thrtau phosphorylation in CTE and CTE with ALS. Neurology 90, e380-e387
29298849   Curated Info

2

Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K (2015) Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment. PLoS One 10, e0145441
26697860   Curated Info

3

Nie J, Duan L, Yan Z, Niu Q (2013) Tau hyperphosphorylation is associated with spatial learning and memory after exposure to benzo[a]pyrene in SD rats. Neurotox Res 24, 461-71
23508864   Curated Info

4

Chai GS, et al. (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124, 388-96
23157378   Curated Info

5

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

6

Edbauer D, et al. (2009) Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8, 681-95
19054758   Curated Info

7

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

8

Yuzwa SA, et al. (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4, 483-90
18587388   Curated Info

9

Chen S, Li B, Grundke-Iqbal I, Iqbal K (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 283, 10513-21
18245083   Curated Info

10

Galas MC, et al. (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281, 19296-304
16675464   Curated Info

11

Gómez-Ramos A, et al. (2006) Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J Neurosci Res 83, 264-73
16397900   Curated Info

12

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

13

Li YK, et al. (2005) [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons.] Sheng Li Xue Bao 57, 154-60
15830099   Curated Info

14

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info