Ser525
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Home > Phosphorylation Site Page: > Ser525  -  Tau (rat)

Site Information
GsRSRtPsLPtPPTR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447929

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 7 ) , mass spectrometry ( 3 , 4 ) , mutation of modification site ( 8 ) , phospho-antibody ( 2 , 5 , 6 , 7 , 8 , 9 , 10 ) , western blotting ( 2 , 5 , 6 , 7 , 8 , 9 )
Disease tissue studied:
Alzheimer's disease ( 5 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 4 ) , 'brain, cerebellum' ( 4 ) , 'brain, cerebral cortex' ( 4 ) , 'brain, hippocampus' ( 2 , 7 ) , brain ( 5 , 6 , 9 , 10 ) , HEK293T (epithelial) ( 8 ) , HeLa (cervical) ( 8 ) , lung ( 4 ) , muscle ( 4 ) , neuron-'brain, hippocampus' ( 8 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 3 ) , PC-12 (chromaffin) ( 3 )

Upstream Regulation
Putative in vivo kinases:
SGK1 (human) ( 8 )
Putative upstream phosphatases:
PPP2CA (rat) ( 7 )
Treatments:
Cdk2/5_inhibitor ( 9 ) , colforsin ( 9 ) , dexamethasone ( 8 ) , DON ( 6 ) , fasting ( 6 ) , folic acid ( 7 ) , homocysteine ( 2 , 7 ) , lithium ( 9 ) , okadaic_acid ( 5 , 6 , 10 ) , PD98059 ( 9 ) , PDGF ( 3 ) , PUGNAc ( 10 ) , Rp-cAMPS ( 9 ) , SB203580 ( 9 ) , vitamin_B12 ( 7 ) , Zn(2+) ( 1 )

References 

1

Xiong Y, et al. (2013) Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34, 745-56
22892311   Curated Info

2

Chai GS, et al. (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124, 388-96
23157378   Curated Info

3

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30
22027198   Curated Info

4

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

5

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

6

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

7

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

8

Yang YC, Lin CH, Lee EH (2006) Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol 26, 8357-70
16982696   Curated Info

9

Liu SJ, et al. (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279, 50078-88
15375165   Curated Info

10

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info