Thr523
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Home > Phosphorylation Site Page: > Thr523  -  Tau (rat)

Site Information
tPGsRSRtPsLPtPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447934

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , phospho-antibody ( 3 , 4 , 5 , 6 ) , western blotting ( 3 , 4 , 5 )
Disease tissue studied:
Alzheimer's disease ( 3 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 5 ) , brain ( 3 , 4 , 6 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 2 )

Upstream Regulation
Treatments:
DON ( 4 ) , fasting ( 4 ) , H2O2 ( 5 ) , heat_shock ( 5 ) , juglone ( 5 ) , okadaic_acid ( 3 , 4 , 6 ) , PUGNAc ( 6 )

References 

1

Pražienková V, et al. (2019) Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons. J Alzheimers Dis
30689580   Curated Info

2

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30
22027198   Curated Info

3

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

4

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

5

Galas MC, et al. (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281, 19296-304
16675464   Curated Info

6

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info