Thr49
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Home > Phosphorylation Site Page: > Thr49  -  HEC1 (human)

Site Information
kLsINkPtsERkVsL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 474512

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 )

Upstream Regulation
Kinases, in vitro:
AurB (human) ( 2 )
Treatments:
nocodazole ( 1 ) , STLC ( 1 ) , TAME ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , cytoskeletal reorganization ( 1 )

References 

1

Kucharski TJ, et al. (2022) Small changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity. J Cell Biol 221
35878017   Curated Info

2

DeLuca JG, et al. (2006) Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127, 969-82
17129782   Curated Info

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