Ser15

Site Information
SGGAGRLsMQELrSQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 474511

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 )
Disease tissue studied:	breast cancer ( 4 ) , breast cancer, triple negative ( 4 )
Relevant cell line - cell type - tissue:	breast ( 4 ) , HeLa (cervical) ( 1 , 2 , 3 ) , HeLa S3 (cervical) [PLK1 (human), knockdown, Tet-inducible PLK1 siRNA] ( 5 ) , HeLa S3 (cervical) ( 5 )

Downstream Regulation
Effects of modification on biological processes:	cell cycle regulation ( 1 , 6 ) , cytoskeletal reorganization ( 2 )

References
1	Sobajima T, et al. (2023) PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. J Cell Biol 222 36897279 Curated Info
2	Kucharski TJ, et al. (2022) Small changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity. J Cell Biol 221 35878017 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
4	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
5	Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457 20860994 Curated Info
6	DeLuca JG, et al. (2006) Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127, 969-82 17129782 Curated Info