Lys25

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Home > Ubiquitylation Site Page: > Lys25 - APE1 (human)

Site Information
rtEPEAkkSkTAAkk SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 6423509

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Disease tissue studied:	colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:	HCT116 (intestinal) ( 1 )

Upstream Regulation
Regulatory protein:	p53 (human) ( 1 )
Treatments:	nutlin-3 ( 1 )

Downstream Regulation
Effects of modification on APE1:	enzymatic activity, altered ( 1 ) , protein degradation ( 1 )

References
1	Busso CS, Iwakuma T, Izumi T (2009) Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene 28, 1616-25 19219073 Curated Info

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