Lys24
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Home > Ubiquitylation Site Page: > Lys24  -  APE1 (human)

Site Information
LrtEPEAkkSkTAAk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6423508

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
p53 (human) ( 2 )
Treatments:
nutlin-3 ( 2 )

Downstream Regulation
Effects of modification on APE1:
enzymatic activity, altered ( 2 ) , protein degradation ( 2 )

References 

1

Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 44, 325-40
21906983   Curated Info

2

Busso CS, Iwakuma T, Izumi T (2009) Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene 28, 1616-25
19219073   Curated Info