Lys27
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Home > Ubiquitylation Site Page: > Lys27  -  APE1 (human)

Site Information
EPEAkkSkTAAkkND   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6423507

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
p53 (human) ( 1 )
Treatments:
nutlin-3 ( 1 )

Downstream Regulation
Effects of modification on APE1:
enzymatic activity, altered ( 1 ) , protein degradation ( 1 )

References 

1

Busso CS, Iwakuma T, Izumi T (2009) Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene 28, 1616-25
19219073   Curated Info