Thr273
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Home > Phosphorylation Site Page: > Thr273  -  TRF1 (human)

Site Information
sKRTRtItSQDKPSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6417401

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 1 , 2 )
Treatments:
ETP47037 ( 1 ) , MK-2206 ( 1 )

Downstream Regulation
Effects of modification on TRF1:
molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , chromatin organization, altered ( 1 ) , transcription, inhibited ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Sánchez-Vázquez R, Martínez P, Blasco MA (2021) AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet 17, e1009410
33690611   Curated Info

2

Chen YC, Teng SC, Wu KJ (2009) Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shortening. Cancer Invest 27, 24-8
19160102   Curated Info

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