Ser714
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Home > Phosphorylation Site Page: > Ser714  -  Tau (mouse)

Site Information
GsIDMVDsPQLATLA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449083

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 2 ) , brain ( 1 )

Upstream Regulation
Treatments:
glycosuria ( 2 ) , hyperglycemia ( 2 ) , hypothermia prone ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 2 ) , Parkinson's disease ( 1 )

References 

1

Credle JJ, et al. (2015) GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein. Cell Death Differ 22, 838-51
25394490   Curated Info

2

Papon MA, et al. (2013) Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice. Diabetes 62, 609-17
22961084   Curated Info

3

Thornton C, et al. (2011) AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. Biochem J 434, 503-12
21204788   Curated Info