Ser794
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Home > Phosphorylation Site Page: > Ser794  -  ATM (human)

Site Information
LSNCTKKsPNKIASG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6413900

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CDK5 (human) ( 1 )
Kinases, in vitro:
CDK5 (human) ( 1 )
Treatments:
camptothecin ( 1 ) , seliciclib ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on ATM:
enzymatic activity, induced ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , cell cycle regulation ( 1 )

References 

1

Tian B, Yang Q, Mao Z (2009) Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol 11, 211-8
19151707   Curated Info