Thr120
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Home > Phosphorylation Site Page: > Thr120  -  CTNNB1 (human)

Site Information
QFdAAHPtNVQRLAE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6406005

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 4 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
prostate cancer ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PRKD1 (human) ( 3 , 4 )
Kinases, in vitro:
PRKD1 (human) ( 4 )
Treatments:
CID755673 ( 3 ) , phosphorylated peptide ( 3 ) , siRNA ( 3 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 1 , 3 , 4 ) , molecular association, regulation ( 2 ) , protein degradation ( 2 )
Effects of modification on biological processes:
cell growth, inhibited ( 4 ) , cell motility, inhibited ( 4 ) , transcription, altered ( 1 ) , transcription, induced ( 4 ) , transcription, inhibited ( 3 )
Induce interaction with:
CTNNA1 (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 3 )

References 

1

Nickkholgh B, et al. (2017) Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer. Oncotarget 8, 78811-78824
29108267   Curated Info

2

Choi SH, et al. (2013) α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes. Genes Dev 27, 2473-88
24240237   Curated Info

3

Du C, et al. (2012) Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network. PLoS One 7, e33830
22511927   Curated Info

4

Du C, Jaggi M, Zhang C, Balaji KC (2009) Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin. Cancer Res 69, 1117-24
19141652   Curated Info