Ser114
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Home > Phosphorylation Site Page: > Ser114  -  BIM (mouse)

Site Information
DKStQtPsPPCQAFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449072

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 2 ) , 293 (epithelial) ( 1 ) , macrophage-peritoneum ( 3 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 1 )
Treatments:
gliotoxin ( 1 ) , insulin ( 2 ) , siRNA ( 1 ) , SP600125 ( 1 )

Downstream Regulation
Effects of modification on BIM:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )
Induce interaction with:
Bcl-2 (human) ( 1 ) , Bcl-xL (human) ( 1 )

References 

1

Geissler A, et al. (2013) Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ 20, 1317-29
23832115   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info