Thr116
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Home > Phosphorylation Site Page: > Thr116  -  BIM (human)

Site Information
SCDKsTQtPsPPCQA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449071

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 3 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 4 ) , western blotting ( 1 , 4 )
Disease tissue studied:
breast cancer ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
starvation_medium ( 1 )

Downstream Regulation
Effects of modification on BIM:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
autophagy, induced ( 1 )
Inhibit interaction with:
LC8 (human) ( 1 ) , beclin 1 (human) ( 1 )

References 

1

Luo S, et al. (2012) Bim inhibits autophagy by recruiting beclin 1 to microtubules. Mol Cell 47, 359-70
22742832   Curated Info

2

Gilley R, et al. (2012) CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIM(EL). Cell Signal 24, 170-80
21924351   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

4

Marani M, et al. (2004) Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene 23, 2431-41
14676826   Curated Info