Lys122
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Home > Acetylation Site Page: > Lys122  -  CREB (mouse)

Site Information
sRRPsyRkILNDLss   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459099

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
liver cancer ( 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , HEK293T (epithelial) ( 2 ) , MCARH7777 (hepatic) ( 2 )

Downstream Regulation
Effects of modification on CREB:
activity, induced ( 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 2 )
Induce interaction with:
SIRT1 (mouse) ( 1 )

References 

1

Fusco S, et al. (2016) A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability. Cell Rep 14, 1195-205
26804914   Curated Info

2

Qiang L, et al. (2011) Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab 14, 758-67
22078933   Curated Info