Ser247
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Home > Phosphorylation Site Page: > Ser247  -  Snail2 (human)

Site Information
KYQCKNCsKTFsRMs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 63243401

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , liver cancer ( 1 ) , hepatocellular carcinoma ( 1 ) , prostate cancer ( 2 )
Relevant cell line - cell type - tissue:
BT-549 (breast cell) ( 2 ) , HCCLM3 (hepatic) ( 1 ) , Huh7 (hepatic) ( 1 ) , LNCaP (prostate cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
H-89 ( 1 ) , KT5720 ( 1 )

Downstream Regulation
Effects of modification on Snail2:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell motility, inhibited ( 1 )
Induce interaction with:
FBXO28 (human) ( 1 )

References 

1

Qiao X, et al. (2023) FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation. Oncogene 42, 2878-2891
37596321   Curated Info

2

Thaper D, et al. (2017) Targeting Lyn regulates Snail family shuttling and inhibits metastasis. Oncogene 36, 3964-3975
28288135   Curated Info

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