Ser461
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Home > Phosphorylation Site Page: > Ser461  -  CEACAM1 (human)

Site Information
FGKtGRAsDQRDLTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6311908

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on CEACAM1:
activity, inhibited ( 2 )
Effects of modification on biological processes:
apoptosis, altered ( 2 )

References 

1

Hu W, et al. (2021) Phosphorylation of human CEACAM1-LF by PKA and GSK3β promotes its interaction with β-catenin. J Biol Chem 297, 101305
34656562   Curated Info

2

Li C, Chen CJ, Shively JE (2009) Mutational analysis of the cytoplasmic domain of CEACAM1-4L in humanized mammary glands reveals key residues involved in lumen formation: stimulation by Thr-457 and inhibition by Ser-461. Exp Cell Res 315, 1225-33
19146852   Curated Info