Ser114
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Home > Phosphorylation Site Page: > Ser114  -  TRF1 (human)

Site Information
AIIHGLSsLTACQLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 63083903

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
NEK7 (human) ( 1 )
Kinases, in vitro:
NEK2 (human) ( 1 )
Treatments:
light ( 1 )

Downstream Regulation
Effects of modification on TRF1:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Induce interaction with:
TINF2 (human) ( 1 )
Inhibit interaction with:
FBXO4 (human) ( 1 )

References 

1

Tan R, et al. (2017) Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1. Mol Cell 65, 818-831.e5
28216227   Curated Info

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