Ser9
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Home > Phosphorylation Site Page: > Ser9  -  SET iso2 (mouse)

Site Information
SAPTAKAsKKELNsN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6308300

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 ) , 'brain, hippocampus' ( 1 ) , 293 (epithelial) ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Regulatory protein:
CK2A1 (human) ( 1 )
Treatments:
beta-amyloid_40 ( 1 ) , CK2_inhibitor ( 1 )

Downstream Regulation
Effects of modification on SET iso2:
intracellular localization ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Zhang Q, et al. (2018) CK2 Phosphorylating I/SET Mediates Tau Pathology and Cognitive Impairment. Front Mol Neurosci 11, 146
29760653   Curated Info

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