Thr493
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr493  -  ALDH1A1 (human)

Site Information
yTEVkTVtVkISQKN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 63070900

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 )
Kinases, in vitro:
AurA (human) ( 1 )

Downstream Regulation
Effects of modification on ALDH1A1:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , protein conformation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:
ALDH1A1 (human) ( 1 )

References 

1

Wang J, et al. (2017) Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer. BMC Biol 15, 10
28193222   Curated Info