Tyr412
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Home > Phosphorylation Site Page: > Tyr412  -  GAK (human)

Site Information
kGDLDISyITSRIAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 63063501

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
HeLa S3 (cervical) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Src (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Fukushima K, et al. (2017) GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase. Cell Cycle 16, 415-427
28135906   Curated Info

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