Tyr203
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Home > Phosphorylation Site Page: > Tyr203  -  ATG3 (mouse)

Site Information
QTRTYDLyITYDkYY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 62940500

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 1 ) , LoVo (intestinal) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Pyk2 (human) ( 1 )
Treatments:
etoposide ( 1 )

Downstream Regulation
Effects of modification on ATG3:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Induce interaction with:
BAG3 (mouse) ( 1 )

References 

1

Ma K, et al. (2017) PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment. Autophagy 13, 579-591
28103122   Curated Info