Tyr142
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Home > Phosphorylation Site Page: > Tyr142  -  CD3Z (mouse)

Site Information
GKGHDGLyQGLsTAT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448932

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , mass spectrometry ( 3 , 4 , 5 , 6 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
brain ( 6 ) , skin ( 1 ) , spleen ( 5 ) , T lymphocyte-lymph node ( 3 ) , thymus ( 4 )

Upstream Regulation
Putative in vivo kinases:
Lck (human) ( 1 )
Kinases, in vitro:
Lck (human) ( 2 )
Treatments:
PP2 ( 1 ) , PP3 ( 1 )

References 

1

Chodaczek G, Papanna V, Zal MA, Zal T (2012) Body-barrier surveillance by epidermal γδ TCRs. Nat Immunol 13, 272-82
22327568   Curated Info

2

Gelkop S, et al. (2012) Development of unique antibodies directed against each of the six different phosphotyrosine residues within the T cell receptor CD3ζ chain. J Immunol Methods 375, 129-37
22020291   Curated Info

3

Iwai LK, Benoist C, Mathis D, White FM (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res 9, 3135-45
20438120   Curated Info

4

Guo A (2009) CST Curation Set: 7710; Year: 2009; Biosample/Treatment: tissue, thymus/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Guo A (2009) CST Curation Set: 7708; Year: 2009; Biosample/Treatment: tissue, spleen/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Zhou J (2009) CST Curation Set: 7383; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: QXp[ST]
Curated Info