Ser314
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Home > Phosphorylation Site Page: > Ser314  -  MDM4 (human)

Site Information
TECKKFNsPSKRYCF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 62381100

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
AXL (human) ( 1 )
Kinases, in vitro:
CDK4 (human) ( 1 ) , P38A (human) ( 1 )

Downstream Regulation
Effects of modification on MDM4:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Induce interaction with:
MDM2 (human) ( 1 )

References 

1

de Polo A, et al. (2017) AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. J Mol Cell Biol 9, 154-165
27927748   Curated Info