Ser87
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Home > Phosphorylation Site Page: > Ser87  -  PPP1R2 (human)

Site Information
GDDEDACsDtEAtEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449054

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 12 ) , mass spectrometry ( 1 , 3 , 5 , 6 , 7 , 8 , 9 , 10 ) , mutation of modification site ( 4 , 11 , 12 ) , phospho-antibody ( 11 ) , phosphoamino acid analysis ( 12 ) , western blotting ( 12 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , Chang liver (cervical) ( 9 ) , COS (fibroblast) ( 11 , 12 ) , endothelial-aorta ( 5 ) , HeLa (cervical) ( 3 , 8 ) , Jurkat (T lymphocyte) ( 6 , 7 , 10 ) , spermatozoa ( 4 )

Upstream Regulation
Kinases, in vitro:
CDK14 (human) ( 2 ) , CK2A1 (human) ( 12 )

Downstream Regulation
Effects of modification on PPP1R2:
intracellular localization ( 12 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Platholi J, et al. (2014) Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase. J Biol Chem 289, 23893-900
25028520   Curated Info

3

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

4

Korrodi-Gregório L, et al. (2013) Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. BMC Cell Biol 14, 15
23506001   Curated Info

5

Verano-Braga T, et al. (2012) Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells. J Proteome Res 11, 3370-81
22497526   Curated Info

6

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

7

Possemato A (2008) CST Curation Set: 5360; Year: 2008; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST](D/E)X(D/E)
Curated Info

8

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

9

Sui S, et al. (2008) Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy. Proteomics 8, 2024-34
18491316   Curated Info

10

Stokes M (2008) CST Curation Set: 3885; Year: 2008; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

11

Sakashita G, et al. (2003) Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. J Biochem (Tokyo) 133, 165-71
12761178   Curated Info

12

Kakinoki Y, Somers J, Brautigan DL (1997) Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle. J Biol Chem 272, 32308-14
9405437   Curated Info

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