Ser121

Site Information
FRTREQEssGEEDND SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 449052

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	'brain, brainstem' ( 3 ) , 'brain, cerebellum' ( 3 ) , 'brain, cerebral cortex' ( 3 ) , adipose tissue ( 3 ) , brain ( 1 ) , heart ( 3 ) , IEC-6 (epithelial) ( 2 ) , intestine ( 3 ) , kidney ( 3 ) , liver ( 3 , 4 ) , lung ( 3 ) , muscle ( 3 ) , pancreas ( 3 ) , spleen ( 3 ) , stomach ( 3 ) , testis ( 3 ) , thymus ( 3 )

Upstream Regulation
Treatments:	corticosterone ( 1 ) , ethanol ( 1 ) , sucrose ( 1 )

References
1	Bertholomey ML, et al. (2018) Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol. Proteomes 6 30322021 Curated Info
2	Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669 23712012 Curated Info
3	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
4	Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729 21738781 Curated Info