Thr73
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Home > Phosphorylation Site Page: > Thr73  -  PPP1R2 (rat)

Site Information
MKIDEPDtPYHNMIG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449051

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 ) , 293 (epithelial) ( 1 ) , GH3 (epithelial) ( 2 )

Upstream Regulation
Treatments:
NMDA ( 1 ) , resveratrol ( 2 ) , SB415286 ( 2 )

Downstream Regulation
Effects of modification on PPP1R2:
molecular association, regulation ( 1 )
Inhibit interaction with:
PPP1CA (rat) ( 1 )

References 

1

Hou H, et al. (2013) Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5. J Cell Biol 203, 521-35
24189275   Curated Info

2

Monteserin-Garcia J, et al. (2013) Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis. FASEB J 27, 1561-71
23292070   Curated Info

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