Ser743
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.8.0
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser743  -  TLK1 (human)

Site Information
PHMRRsNssGNLHMA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449050

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 1 ) , mutation of modification site ( 4 ) , peptide sequencing ( 4 ) , phospho-antibody ( 2 , 3 ) , phosphoamino acid analysis ( 4 ) , phosphopeptide mapping ( 4 ) , western blotting ( 2 , 3 )
Disease tissue studied:
lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) [CD38 (human), transfection, Lentiviral particles containing CD38 vector were transfected] ( 1 ) , A549 (pulmonary) ( 1 ) , HCC2279 (pulmonary) ( 3 ) , HeLa (cervical) ( 2 ) , T98G (glial) ( 4 ) , U2OS (bone cell) [GR (human)] ( 4 )

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 4 )
Kinases, in vitro:
Chk1 (human) ( 4 )
Treatments:
caffeine ( 4 ) , ionizing_radiation ( 2 , 3 ) , UCN-01 ( 4 )

Downstream Regulation
Effects of modification on TLK1:
enzymatic activity, inhibited ( 4 )

References 

1

Wang W, et al. (2018) Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. Mol Cell Proteomics
29980616   Curated Info

2

Kelly R, Davey SK (2013) Tousled-like kinase-dependent phosphorylation of rad9 plays a role in cell cycle progression and g2/m checkpoint exit. PLoS One 8, e85859
24376897   Curated Info

3

Kodym E, Kodym R, Choy H, Saha D (2008) Sustained metaphase arrest in response to ionizing radiation in a non-small cell lung cancer cell line. Radiat Res 169, 46-58
18159951   Curated Info

4

Groth A, et al. (2003) Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J 22, 1676-87
12660173   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.