Thr86
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Home > Phosphorylation Site Page: > Thr86  -  p73 (human)

Site Information
AASASPYtPEHAASV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449047

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 2 , 3 ) , phosphoamino acid analysis ( 1 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
brain cancer ( 3 ) , glioblastoma ( 3 ) , glioblastoma multiforme ( 3 ) , glioma ( 3 ) , lung cancer ( 2 , 3 ) , non-small cell lung cancer ( 2 , 3 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
p73 (human) ( 2 )
Putative in vivo kinases:
CDK1 (human) ( 1 , 3 ) , CDK2 (human) ( 1 , 3 )
Kinases, in vitro:
CDK1 (human) ( 1 ) , CDK2 (human) ( 3 )
Treatments:
nocodazole ( 2 ) , seliciclib ( 3 ) , serum_starvation ( 3 )

Downstream Regulation
Effects of modification on p73:
activity, inhibited ( 3 ) , intracellular localization ( 2 ) , protein degradation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , chromatin organization, altered ( 2 ) , transcription, inhibited ( 3 )
Inhibit interaction with:
p73 (human) ( 2 )

References 

1

Benosman S, et al. (2011) Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. J Biol Chem 286, 43013-25
22002055   Curated Info

2

Merlo P, et al. (2005) A role of p73 in mitotic exit. J Biol Chem 280, 30354-60
15985436   Curated Info

3

Gaiddon C, et al. (2003) Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem 278, 27421-31
12676926   Curated Info