Tyr142
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Home > Phosphorylation Site Page: > Tyr142  -  CTNNB1 (human)

Site Information
AVVNLINyQDDAELA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449044

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 , 6 , 9 , 12 ) , mass spectrometry ( 5 ) , mass spectrometry (in vitro) ( 9 ) , mutation of modification site ( 6 , 9 , 10 , 12 ) , phospho-antibody ( 2 , 3 , 4 , 7 , 8 , 9 , 10 ) , western blotting ( 2 , 3 , 4 , 6 , 7 , 8 , 9 , 10 )
Disease tissue studied:
chondrosarcoma ( 7 ) , colorectal cancer ( 4 , 9 ) , colorectal carcinoma ( 4 , 9 ) , leukemia ( 10 ) , chronic myelogenous leukemia ( 10 ) , lung cancer ( 5 ) , non-small cell lung adenocarcinoma ( 5 ) , ovarian cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Fer (human) ( 3 ) , Src (human) ( 10 )
Putative in vivo kinases:
EGFR (human) ( 7 ) , FGFR2 (human) ( 7 ) , FGFR3 (human) ( 7 ) , TrkA (human) ( 7 )
Kinases, in vitro:
Brk (human) ( 9 ) , EGFR (human) ( 7 ) , FGFR2 (human) ( 7 ) , FGFR3 (human) ( 7 ) , TrkA (human) ( 7 )
Treatments:
conditioned medium ( 2 ) , CTGF ( 8 ) , FGF2 ( 7 ) , HGF ( 12 ) , imatinib ( 10 ) , refametinib ( 2 ) , SB216763 ( 10 ) , SKI-606 ( 10 ) , sorafenib ( 2 ) , U0126 ( 4 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 2 , 12 ) , molecular association, regulation ( 6 , 12 ) , protein degradation ( 6 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , carcinogenesis, induced ( 2 ) , cell growth, induced ( 2 ) , signaling pathway regulation ( 7 )
Induce interaction with:
Bcl-9L (human) ( 12 ) , CTNNA1 (human) ( 6 )

References 

1

Weng J, et al. (2021) Advanced glycation end products induce endothelial hyperpermeability via β-catenin phosphorylation and subsequent up-regulation of ADAM10. J Cell Mol Med
34227224   Curated Info

2

Huynh H, et al. (2019) Sorafenib/MEK inhibitor combination inhibits tumor growth and the Wnt/β‑catenin pathway in xenograft models of hepatocellular carcinoma. Int J Oncol 54, 1123-1133
30747223   Curated Info

3

Fan G, et al. (2016) HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer. Genes Dev 30, 1542-57
27401557   Curated Info

4

Lemieux E, et al. (2015) Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer. Oncogene 34, 4914-27
25500543   Curated Info

5

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

6

Choi SH, et al. (2013) α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes. Genes Dev 27, 2473-88
24240237   Curated Info

7

Krejci P, et al. (2012) Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation. PLoS One 7, e35826
22558232   Curated Info

8

Rooney B, et al. (2011) CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy. FEBS Lett 585, 531-8
21237163   Curated Info

9

Palka-Hamblin HL, et al. (2010) Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 123, 236-45
20026641   Curated Info

10

Coluccia AM, et al. (2007) Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J 26, 1456-66
17318191   Curated Info

11

Sampietro J, et al. (2006) Crystal structure of a beta-catenin/BCL9/Tcf4 complex. Mol Cell 24, 293-300
17052462   Curated Info

12

Brembeck FH, et al. (2004) Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev 18, 2225-30
15371335   Curated Info