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Site Information |
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AVVNLINyQDDAELA SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 449044 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
Putative in vivo kinases: | |
Kinases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on CTNNB1: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
References | |
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Chen Z, et al. (2024) Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9. Cell Commun Signal 22, 182
38491522 Curated Info |
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Weng J, et al. (2021) Advanced glycation end products induce endothelial hyperpermeability via β-catenin phosphorylation and subsequent up-regulation of ADAM10. J Cell Mol Med 25
34227224 Curated Info |
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Huynh H, et al. (2019) Sorafenib/MEK inhibitor combination inhibits tumor growth and the Wnt/β‑catenin pathway in xenograft models of hepatocellular carcinoma. Int J Oncol 54, 1123-1133
30747223 Curated Info |
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Fan G, et al. (2016) HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer. Genes Dev 30, 1542-57
27401557 Curated Info |
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Lemieux E, et al. (2015) Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer. Oncogene 34, 4914-27
25500543 Curated Info |
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Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448 Curated Info |
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Choi SH, et al. (2013) α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes. Genes Dev 27, 2473-88
24240237 Curated Info |
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Krejci P, et al. (2012) Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation. PLoS One 7, e35826
22558232 Curated Info |
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Rooney B, et al. (2011) CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy. FEBS Lett 585, 531-8
21237163 Curated Info |
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Palka-Hamblin HL, et al. (2010) Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 123, 236-45
20026641 Curated Info |
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Coluccia AM, et al. (2007) Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J 26, 1456-66
17318191 Curated Info |
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Sampietro J, et al. (2006) Crystal structure of a beta-catenin/BCL9/Tcf4 complex. Mol Cell 24, 293-300
17052462 Curated Info |
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Brembeck FH, et al. (2004) Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev 18, 2225-30
15371335 Curated Info |